Magnesium glycinate is generally safe for most healthy adults, but if you’re taking prescription medications, it’s smart to check for possible interactions first. Magnesium can affect how certain drugs are absorbed or metabolized.
💊 Common Medication Interactions
According to the National Institutes of Health (NIH), magnesium supplements may interact with:
- Antibiotics – Especially tetracyclines and fluoroquinolones (e.g., ciprofloxacin), which may bind to magnesium and reduce antibiotic effectiveness
- Diuretics – Can increase magnesium loss or retention, depending on the type
- Bisphosphonates (used for osteoporosis) – Magnesium can reduce absorption if taken at the same time
- Proton Pump Inhibitors (PPIs) – Long-term use may lower magnesium levels, making supplementation helpful but also requiring supervision
🕐 Timing Matters
If you’re taking any of the above medications, separate magnesium glycinate doses by at least 2–4 hours to reduce interference with absorption.
✅ Talk to Your Doctor or Pharmacist
While magnesium glycinate is well-tolerated and gentle on the stomach, always consult with your healthcare provider if you’re:
- Taking prescription medications
- Managing chronic health conditions
- Pregnant or nursing
📚 Backed by Research
For a complete list of drug interactions with magnesium, visit the NIH Magnesium Fact Sheet.
🛒 Trusted Magnesium Picks
We’ve curated a list of top-rated magnesium glycinate supplements designed for quality, absorption, and minimal side effects—perfect if you’re also managing other health concerns.